COMPLETE LINE OF TOPICAL ANESTETICS. Topical anesthetics are medications applied to the skin or mucous membranes to numb and minimize pain. Commonly used for Permanent Makeup, Microblading, Tattooing, Piercing. They can also be used for pain relief from minor cuts, insect bites, and minor burns. Topical anesthetics can be purchased as over-the-counter (or by prescription strength medications).